Journal: Radiation research

Article Title: Cutaneous Radiation Injuries: Models, Assessment and Treatments

doi: 10.1667/RADE-20-00120.1

Figure Lengend Snippet: Topics Addressed During the Discussion Sessions

Article Snippet: US Biotest (San Luis Obispo, CA) has received U.S. Government funding to develop a guinea pig model for CRI, to test their MCM candidate, DSC127 (also called USB001) ( 90 ).

Techniques: Animal Model, Selection, Infection, Derivative Assay

Journal: Radiation research

Article Title: Cutaneous Radiation Injuries: Models, Assessment and Treatments

doi: 10.1667/RADE-20-00120.1

Figure Lengend Snippet: Skin MCM Studies Supported by the NIAID

Article Snippet: US Biotest (San Luis Obispo, CA) has received U.S. Government funding to develop a guinea pig model for CRI, to test their MCM candidate, DSC127 (also called USB001) ( 90 ).

Techniques: Ex Vivo, Recombinant, Derivative Assay

Journal:

Article Title: Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

doi: 10.1159/000097246

Figure Lengend Snippet: Construction of the 3D model of the guinea pig model. ST = Scala tympani; SV = scala vestibuli; ELS = endolymphatic space; SL = spiral ligament. A Cross-sectional view of one turn of the guinea pig cochlea. B Schematic showing the relevant ‘radial’ pharmacokinetic processes. Drugs are allowed to diffuse between the various compartments according to the respective concentration gradients and to the permeability at the specific border between two compartments as indicated by the arrows. C Simplified structure from B with pharmacokinetic processes incorporated into the 3D model. In addition, there is diffusion within the compartments along their longitudinal axis and through the helicotrema. D 3D model of the guinea pig cochlea in ANSYS based on the simplified cross-sectional view shown in C and on the functions describing the change of crosssectional area along distance shown in figure 2.

Article Snippet: D 3D model of the guinea pig cochlea in ANSYS based on the simplified cross-sectional view shown in C and on the functions describing the change of crosssectional area along distance shown in .

Techniques: Concentration Assay, Permeability, Diffusion-based Assay

Journal:

Article Title: Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

doi: 10.1159/000097246

Figure Lengend Snippet: The 3D model of the guinea pig cochlea (fig. 1D) is based on the functions describing the change of cross-sectional area (CSA) for the fluid spaces of the ST and SV area along distance as published by Thorne et al. [1999] (open symbols) and their analytical approximation (lines). The following functions were fitted to the published cross-sectional area curves of SV and ST of the guinea pig cochlea:

Article Snippet: D 3D model of the guinea pig cochlea in ANSYS based on the simplified cross-sectional view shown in C and on the functions describing the change of crosssectional area along distance shown in .

Techniques:

Journal:

Article Title: Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

doi: 10.1159/000097246

Figure Lengend Snippet: A simplified geometry (insert in fig. 4 and ‘Appendix B’) was used to compare results from 3D with 1D simulations. A Concentration profiles with distance for the three models, the 3D model (ANSYS), the dimensionally reduced model (1D-ITWM) and the existing 1D model (Washington University Cochlear Fluids Simulator, FluidSim) calculated after an application time of 60000 s (1000 min) to the base. There is excellent agreement between the three models along the length of the structure. B Calculated concentration time courses for the middle of the structure (7.5 mm from the base, arrow). There is good correspondence between the three models for calculation times less than 25000 s (400 min).

Article Snippet: D 3D model of the guinea pig cochlea in ANSYS based on the simplified cross-sectional view shown in C and on the functions describing the change of crosssectional area along distance shown in .

Techniques: Concentration Assay

Journal:

Article Title: Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

doi: 10.1159/000097246

Figure Lengend Snippet: Sample calculation for the 3D-ANSYS model. The figure shows the saturation situation after continuous application of a substance to the round window membrane using the parameters from table 1.

Article Snippet: D 3D model of the guinea pig cochlea in ANSYS based on the simplified cross-sectional view shown in C and on the functions describing the change of crosssectional area along distance shown in .

Techniques: Membrane

Journal:

Article Title: Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

doi: 10.1159/000097246

Figure Lengend Snippet: Parameters used for comparison of the three modeling approaches

Article Snippet: D 3D model of the guinea pig cochlea in ANSYS based on the simplified cross-sectional view shown in C and on the functions describing the change of crosssectional area along distance shown in .

Techniques: Comparison, Diffusion-based Assay, Permeability, Concentration Assay